Human identification with STRs and SNPs
Simultaneously sequence multiple forensic STRs and SNPs in one test
Simplified STR & SNP Analysis
Many forensic labs currently utilize PCR and capillary electrophoresis (CE)-based methods to analyze short tandem repeat (STR) markers and other polymorphisms. However, sequencing STRs grants an additional level of resolution for determining differences between individuals, including the ability to see intra-STR single nucleotide polymorphisms, or SNPs. SNPs can be used for identification when DNA is too degraded for STR analysis, or to provide physical and biogeographical estimation for investigative intelligence.
Benefits of SNP & STR Analysis with NGS
- STR sequencing can resolve alleles of identical size, but different sequence
- High-throughput sequencing lets you simultaneously analyze multiple polymorphisms
- Multiple STR types can be analyzed at once, without the need for re-testing
SNPs provide investigative intelligence
From DNA to Identification
- Forensic genetic genealogy—Expand your network of information to identify an individual
- Mitochondrial DNA sequencing—Extract more answers from challenging samples
- STRs and SNPs sequencing—Translate samples into physical traits
This overview showcases how these unique capabilities advance DNA analysis from generating a profile to providing a human identification.
STR and SNP Sequencing Workflow
DNA Extraction & Quantitation
We recommend using your current DNA extraction and quantitation methods.
Library Preparation
ForenSeq DNA Signature Prep Kit (for nuclear DNA) Assay approximately 200 genetic markers in a single test. Includes all reagents to prepare sequencing libraries from forensic DNA samples.
MiSeq FGx Instrument
First fully validated next-generation sequencing system for forensic genomics.
MiSeq FGx Reagent Kit
Pre-filled, ready-to-use reagent cartridges, specifically designed for the MiSeq FGx System.
ForenSeq Universal Analysis Software
Full functionality to analyze and interpret a wide range of forensic casework and database samples.
Uses of SNP and STR Analysis
Criminal Casework
Targeted sequencing of forensically relevant STR and SNP loci empowers you to generate leads, even on cold cases. Learn More »
Forensic DNA Databases
NGS can help labs produce high-quality forensic profiles for national DNA databases, with a faster turnaround. Learn More »
Identifying Missing Persons
NGS delivers a single platform and workflow to overcome the wide range of difficult samples encountered in missing persons cases. Learn More »
Disaster Victim Identification
Genetic analysis of mass fatality evidence with NGS lets you extract as much information as possible from highly compromised samples. Learn More »
Additional Resources
Overview: NGS for Forensic Genomics
Take a Genomic Leap Forward in Forensic Science
Harnessing NGS to Solve Crimes
Recreating a Face Based on DNA
Talk to a Forensic Expert
We create thoughtfully tailored genomic solutions for forensic DNA labs.
Let us help you overcome limitations and solve more cases.
